|Description||CXCL16 rabbit polyclonal|
|Protein full name||C-X-C motif chemokine 16|
|Synonyms||Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Srpsox, SR-PSOX, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, Cxcl16|
|Immunogen||Recombinant protein corresponding to
|Predicted MW.||27 kDa|
|Observed MW.||28-35 kDa|
|Uniprot ID||Q8BSU2, Q6AXU5|
|WB||Mouse, Rat||1: 500-1: 1000||lung, lymph node, stomach|
CXCL16 belongs to the CXC chemokine family, which is synthesised in plasmacytoid dendritic cell as a transmembrane molecule. It exists in a transmembrane and soluble form. The transmembrane form of CXCL16 functions as an adhesion molecule for CXCR6-expressing cells, whereas the soluble form of CXCL16 mediates infiltration of circulating cells into sites of injury. CXCL16, has been proposed as an important pathogenic mediator in inflammatory diseases, including rheumatoid arthritis, glomerulonephritis, or prostate cancer. CXCL16 has been implicated in some forms of renal disease such as lupus nephritis and antiglomerular basement membrane nephritis. CXCL16 also plays a pivotal role in the pathogenesis of angiotensin II–induced renal injury and fibrosis through regulation of macrophage and T cell infiltration and bone marrow–derived fibroblast accumulation.
Western blot analysis of CXCL16 (GB111441)
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.|
|Storage Buffer||PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.|
NOTE: This product is intended for research only.